Clinical Trials

Participants in clinical trials can play a more active role in their own health care, gain access to new research treatments before they are widely available, and help others by contributing to medical science.

Here at VISOC, we pride ourselves on cutting edge therapy and the development of new technologies to improve patient care. We are currently participating in a number of clinical trials involving several therapeutic areas which are listed below.

Next to the title of each trial is the Clinical Trials.gov Identifier number. You can go to www.clinicaltrials.gov to learn more about each trial. If you are interested in learning more about your participation, or the participation of a loved one, please contact Mahmood Razavi, M.D. at (714) 560-4450.

**Currently Enrolling Trials**

  • Resistant Hypertension
    • SYMPLICITY HTN-3 Trial - NCT01418261 (Open to Enrollment)
      Site Principal Investigator: Mahmood Razavi, M.D.
      Renal Denervation in Patients with Uncontrolled Hypertension (HTN-3)

    One of the body's primary methods for controlling blood pressure involves the sympathetic nervous system. This system includes the major organs that are responsible for regulating blood pressure: the brain, the heart, the kidney and the blood vessels themselves. One key player in long term blood pressure regulation is the kidney. Renal nerves communicate information from the kidney to the brain, and vice versa. In people with hypertension, the renal nerves are hyperactive, which raises blood pressure and contributes to heart, kidney and blood vessel damage.

    Renal Denervation (RDN) treatment is being studied in a clinical trial to learn whether renal denervation is a safe and effective treatment option to lower blood pressure for certain patients with uncontrolled hypertension. The SYMPLICITY HTN-3 clinical trial will attempt to disrupt the hyperactive nerves by applying brief radio frequency (RF) energy near the nerves with an experimental medical device.

    A single procedure is performed by inserting a tube in the groin and placing the device in the artery leading to the kidney. Using RF, multiple treatments are performed in each artery to disrupt the hyperactive nerves. Following treatment, the device is removed.

    To learn more about this trial, please visit www.symplifyBPtrial.com.

  • Peripheral Arterial Disease and Claudication

    Claudication is pain, tired or weak feeling that occurs in your legs, usually during activity such as walking. The symptoms typically begin when you start to exercise, and go away a short time after you rest. When the arteries that carry blood to your legs become narrowed or blocked, your leg muscles may not receive enough of the blood and oxygen they need to support physical activity.

    Your arteries are normally smooth and unobstructed on the inside but, as you age, they can become blocked through a process called atherosclerosis, also called "hardening of the arteries." As you age, a sticky substance called plaque can build up in the walls of your arteries. Plaque is made up of cholesterol, calcium, and fibrous tissue. As more plaque builds up, your arteries can narrow and stiffen. Eventually, enough plaque builds up to reduce blood flow to your leg arteries.

    • LEVANT Continued Access Registry - NCT01412541 (Open to Enrollment)
      Site Principal Investigator: Mahmood Razavi, M.D.

      While several options exist for treating PAD, including drug therapy, standard balloon angioplasty, stents, and surgery, there are still patients who are not qualified for, or do not get relief of their symptoms with these therapies. LEVANT Continued Access Registry will research how effective a new technology, the Moxy balloon, is at preventing diseased leg arteries from re-narrowing over time. The Moxy balloon is a new drug-coated balloon catheter that delivers paclitaxel to the arterial wall in a single, short inflation. Paclitaxel is an anti-proliferative drug commonly used to prevent arterial restenosis.

  • Deep Vein Thrombosis

    Deep vein thrombosis, or DVT, is a blood clot that forms in a vein deep in the body. Blood clots occur when blood thickens and clumps together. Most deep vein blood clots occur in the lower leg or thigh. They also can occur in other parts of the body. A blood clot in a deep vein can break off and travel through the bloodstream. The loose clot is called an embolus. It can travel to an artery in the lungs and block blood flow. This condition is called pulmonary embolism or PE. PE is a very serious condition. It can damage the lungs and other organs in the body and cause death.

    • ATTRACT - NCT00790335 (Open to Enrollment)
      Site Principal Investigator: Mahmood Razavi, M.D.
      Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
      To learn more about this study, please visit www.attract.wustl.edu

  • Other areas of clinical trial experience include:
    • Carotid Stenosis (Previous participation in the ACT1, CHOICE & SAPPHIRE WW Trials
      • Carotid artery stenting for both standard risk, asymptomatic patients and for high risk, symptomatic patients.
    • Hypertension
      • Carotid artery baroreceptor stimulation
      • Renal Artery Stenosis (stenting vs. drug therapy)
    • Acute Ischemic Stroke
      • Device assisted thrombectomy
    • Cerebral Aneurysms
      • Endovascular coiling
    • Pulmonary Embolism
      • Inferior Vena Cava filter(s)
    • Surgical Hemostasis
      • Peripheral Arterial Bypass
      • Hemodialysis procedures

To find out more information, please contact:

Mahmood Razavi, M.D
Director of Clinical Trials
(714) 560-4450
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